Estado de nutrición de niñas y niños menores de cinco años en México. Ensanut 2022.

OBJETIVO: Actualizar las prevalencias de desnutrición infantil y de sobrepeso más obesidad en menores de cinco años de México, en el ámbito nacional y por grupos de edad y su distribución por variables sociodemográficas. Material y métodos. Se analizó la información de 1 684 menores de cinco años de la Encuesta Nacional de Salud y Nutrición 2022 (Ensanut 2022). Se estimaron prevalencias con IC95%, ajustadas por el diseño del estudio, de bajo peso, baja talla, emaciación y sobrepeso más obesidad y su distribución por variables sociodemográficas: tipo de localidad y región de residencia. RESULTADOS: Actualmente, 4.1% tienen bajo peso, 12.8% baja talla y 0.8% emaciación. El sobrepeso más obesidad es de 7.7%. En el Pacífico-Sur y la Península, la baja talla es de 20%. Conclusión. La baja talla es el principal problema de nutrición entre los preescolares, notablemente en los mayores de 24 meses y en los estados del sur. En 12 años se ha estancado la desnutrición crónica en México. La Ensanut 2022 contribuye con información actualizada que permite la focalización de las estrategias hacia las zonas y grupos más vulnerables en México.

Proximal determinants of suboptimal early child development during the first three years of life in socially deprived Mexican contexts.

Assessing the status and determinants of early child development (ECD) requires accurate and regularly updated measurements. Yet, little information has been published on the subject in low- and middle-income countries, particularly regarding the proximal determinants of childhood development in contexts of high social marginalization. This article analyzes the factors that favor or mitigate suboptimal ECD outcomes in Mexico. A cross-sectional study was conducted using recently collected data for 918 children aged 0-38 months from socially marginalized communities in 23 Mexican municipalities. The ECD outcomes of the children were estimated based on indicators of chronic undernutrition and neurodevelopment (normal, lagging and at risk of delay). The distribution of outcomes was described across the ECD proximal determinants analyzed, including the co-occurrence of chronic undernutrition and suboptimal neurodevelopment. Covariate-adjusted prevalence of the ECD outcomes and co-occurrences were calculated as post-estimations from a multiple multinomial logistic regression. The prevalence of chronic undernutrition was 23.5%; 45.9% of children were classified with neurodevelopmental lag, and 11% at risk of neurodevelopmental delay. The prevalence of stunting co-occurring with suboptimal neurodevelopment came to 15.4%. The results of the multinomial logistic regression model indicated that early gestational age, low birth weight, a low household socioeconomic level, being male and having numerous siblings were all associated with the co-occurrence of chronic undernutrition and suboptimal child neurodevelopment. This study identified important predictors of child development in the first three years of life, specifically in two of its principal indicators: nutritional and neurodevelopmental status. Most of the predictors observed can be improved by means of social programs and interventions. Trial registration: ClinicalTrials.gov ID: NCT04210362.

Differential Effects of Three Nutritional Supplements on the Nutrient Intake of Pregnant Women Enrolled in a Conditional Cash Transfer Program in Mexico: A Cluster Randomized Trial.

Supplementation in malnourished pregnant women should not displace natural healthy foods. Objective: To estimate the differential effects of three nutritional supplements on macro- and micronutrient intake of pregnant women beneficiaries of the conditional cash transfer program Prospera (CCT-POP). Methods: Prospective cluster randomized trial. Communities were randomly assigned to receive a fortified beverage (Beverage), micronutrient tablets (Tablets), or micronutrient powder (MNP). Pregnant women (at <25 weeks) were recruited. The food frequency questionnaire was applied at 25 and 37 weeks of pregnancy and at one and three months postpartum (mpp). Differential effects of the three supplements on the median change in nutrient intake from baseline to each follow-up stage were estimated. Results: Median change in protein intake from dietary and supplement sources were significantly lower for MNP and Tablets than for Beverages (baseline to 37 w: −7.80 ± 2.90 and −11.54 ± 3.00, respectively; baseline to 1 mpp: −7.34 ± 2.90 for MNP, p < 0.001). Compared to Beverages, median increases were higher for the MNP for vitamins C (31.2 ± 11.7, p < 0.01), E (1.67 ± 0.81, p < 0.05), and B12 (0.83 ± 0.27, p < 0.01) from baseline to 37 wk; from baseline to 1 mpp, there was a higher median increase in B12 (0.55 ± 0.25, p < 0.05) and folate (63.4 ± 24.3, p < 0.01); and from baseline to 3 mpp, a higher median increase in iron (2.38 ± 1.06, p < 0.05) and folate (94.4 ± 38.1, p < 0.05). Conclusions: Intake of micronutrients was higher for MNP and Tablets, likely due to food displacement among Beverage consumers. Although iron bioavailability and absorption inhibitors were not considered for the present analyses, the distribution of Tablets or MNP had several advantages in this context where micronutrient deficiency remains high among pregnant women, but macronutrient intake is generally adequate or even high.

Early neurological development and nutritional status in Mexican socially deprived contexts.

Early childhood development (ECD) is a critical stage in the intergenerational process of human development. Targeted interventions depend on accurate and up-to-date ECD measurements. This paper presents estimates for the nutritional and neurodevelopmental status of socially marginalized children in Mexico. We performed a cross-sectional study based on data collected in 2019-2020 during home visits to 1,176 children aged 0-38 months across 24 highly marginalized locations in Oaxaca. We assessed nutritional status according to the World Health Organization 2006 child-growth standards and ECD status using the Child Development Evaluation Test, 2nd Edition. We stratified results by sex. Prevalence of stunting was 5.3 percentage points (p.p.) higher (p = 0.023) in males (25.3%; 95% CI: 20.2%, 31.1%) compared to females (20.0%; 95% CI: 15.0%, 26.1%). Overall prevalence rates stood at 5.7% (95% CI: 4.0%, 8.1%) for underweight, 1.5% (95% CI: 0.9%, 2.7%) for wasting and 3.6% (95% CI: 2.3%, 5.7%) for overweight/obesity, with no significant differences by sex. Prevalence of normal development was 8.3 p.p. lower (p = 0.001) in males (39.3%; 95% CI: 34.5%, 44.4%) compared to females (47.6%; 95% CI: 41.6%, 53.6%). By development area, the highest prevalence of suboptimal outcomes among children with developmental lag or at risk of delay was observed in their gross motor and language skills: 24.1% (95% CI: 20.0%, 28.8%) and 38.6% (95% CI: 34.0%, 43.3%), respectively. The largest difference between the sexes was found in the language area. Our results show that childhood development strategies have been insufficient thus far in the studied population. Programs specifically designed to prevent ECD lags and bridge inequality gaps are urgently needed. Trial registration: ClinicalTrials.gov ID: NCT04210362.

Assessing the effect of an educational intervention on early childhood development among Mexican preschool children in the state of Oaxaca: a study protocol of a cluster randomized stepped-wedge trial.

BACKGROUND: Early childhood development (ECD) is essential in human capacity building and a critical element in the intergenerational process of human development. In some countries, social programs targeted at improving ECD have proven to be successful. Oaxaca is one of the States with the greatest social inequities in Mexico. Therefore, children in Oaxaca are at a high risk of suboptimal ECD. In 2014, the non-governmental organization (NGO) Un Kilo de Ayuda started to implement the Neurological and Psycho-affective Early Childhood Development Program in eighty marginalized communities of Oaxaca. In this article, we present the impact evaluation design to estimate the effect of this program on ECD. METHODS: We will use a cluster randomized stepped-wedge design with an allocation ratio of 1:1. Communities will be randomly assigned to each study group: four groups of twenty communities each. We expect that children from intervened communities will show better ECD outcomes. DISCUSSION: This study is one of the few rigorous assessments of the effect of an ECD program on the neurodevelopment of Mexican children recruited in their first 3 years of life from communities of high social vulnerability. Our study design is recommended when the way in which outcomes are measured and assessed depends on age, self-selection is present, and assignment is performed at an aggregate level. Implementation research will be conducted prior to study launch and quality control measures will be in place to maximize the fidelity of study design implementation. TRIAL REGISTRATION: ClinicalTrials.gov NCT04210362.

Magnitud y tendencia de la desnutrición y factores asociados con baja talla en niños menores de cinco años en México, Ensanut 2018-19 / Magnitude and trends of malnutrition, and stunting associated factors among children under five years old in Mexico, Ensanut 2018-19

Resumen Objetivo: Actualizar la prevalencia de desnutrición y sus tendencias en los últimos 30 años e identificar factores asociados con la baja talla en una muestra representativa nacional de niños <5 años en México. Material y métodos: Se estimaron prevalencias de desnutrición en <5 años en 2018-19 y se compararon con prevalencias de los últimos 30 años. Se estudiaron asociaciones de factores geográficos, del hogar, maternos e individuales con baja talla, utilizando regresión logística múltiple. Resultados: El 4.8% de los niños <5 años presentó bajo peso, 14.2% baja talla y 1.4% emaciación. Entre 1988-2012 hubo un descenso en baja talla interrumpido entre 2012-2018. La baja talla se asoció positivamente con residencia rural, región Sur, hogares más pobres, madres indígenas y mayor número de hijos, y negativamente con diversidad dietética. Conclusiones: La desnutrición crónica es un problema persistente asociado con factores de vulnerabilidad social, cuya tendencia descendente de 30 años se interrumpió entre 2012-2018. Es imperativo implementar una estrategia nacional de prevención de baja talla.

Abstract Objective: To update malnutrition prevalence and its trends over the last 30 years and identify factors associated with stunting in a national sample of children <5 y in Mexico. Materials and methods: Malnutrition prevalences in children <5 y in 2018-19 were compared with prevalences from the previous 30 years. Associations of stunting with geographic, household, maternal and individual factors were assessed using multiple logistic regressions. Results: 4.8% of children <5 y were underweight, 14.2% stunted and 1.4% wasted. Between 1988-2012 a decreasing trend in stunting was observed that was interrupted between 2012-2018. Stunting was positively associated with children living in rural localities, the Southern Region, poorer households, with indigenous mothers or whose mothers had a greater number of children. A negative association was found with diet diversity. Conclusions: Stunting is a persistent problem associated with social vulnerability that had been declining in the last 30 years; however its descending trend was inter- rupted between 2012 and 2018. It is imperative to implement a national strategy for the prevention of stunting.

Magnitud y tendencia de la desnutrición y factores asociados con baja talla en niños menores de cinco años en México, Ensanut 2018-19.

Objetivos. Actualizar la prevalencia de desnutrición y sus tendencias en los últimos 30 años e identificar factores asociados con la baja talla en una muestra representativa nacional de niños <5 años en México. Material y méto-dos. Se estimaron prevalencias de desnutrición en <5 años en 2018-19 y se compararon con prevalencias de los últimos 30 años. Se estudiaron asociaciones de factores geográficos, del hogar, maternos e individuales con baja talla, utilizando regresión logística múltiple. Resultados. El 4.8% de los <5 años presentó bajo peso, 14.2% baja talla y 1.4% emaciación. Entre 1988-2012 hubo un descenso en baja talla interrum-pido entre 2012-2018. La baja talla se asoció positivamente con residencia rural, región sur, hogares más pobres, madres indígenas y mayor número de hijos, y negativamente con diversidad dietética. Conclusiones. La desnutrición cró-nica es un problema persistente asociado con factores de vulnerabilidad social, cuya tendencia descendente de 30 años se interrumpió entre 2012-2018. Es imperativo implementar una estrategia nacional de prevención de baja talla.

A Fortified Food Can Be Replaced by Micronutrient Supplements for Distribution in a Mexican Social Protection Program Based on Results of a Cluster-Randomized Trial and Costing Analysis.

BACKGROUND: Despite positive nutrition impacts, the prevalence of malnutrition among beneficiaries of Mexico's conditional cash transfer (CCT) program remains high. Greater nutrition impact may have been constrained by the type of nutritional supplements provided. OBJECTIVE: The objective of this study was to inform a potential modification to the supplements distributed to pregnant and lactating women and children. METHODS: Impact was assessed using 2 cluster-randomized trials (pregnant women, children) run simultaneously. Communities (n = 54) were randomly assigned to the fortified foods provided by the program (Nutrivida women, Nutrisano children) or alternatives: tablets (women), syrup (children), or micronutrient powders for women (MNP-W) and children (MNP-C). Each supplement for women/children contained the same micronutrients based on the formulations of Nutrivida and Nutrisano, respectively. Pregnant women (aged >18 y) were recruited before 25 weeks of gestation and followed to 3 mo postpartum. Children aged 6-12 mo were recruited and followed to age 24 mo. Primary outcomes were anemia for women and length growth for children. Statistical analyses appropriate for cluster-randomized designs were used, and structural equation modeling to estimate dose-response effects. Supplement costs per beneficiary (daily dose for 18 mo) were estimated for production and distribution. RESULTS: There was no significant difference in change of anemia prevalence between supplement groups in women, or in length growth between groups in children. One daily dose of any supplement was associated with 0.8 cm greater length growth. From baseline to age 24 mo, the prevalence of anemia in the Nutrisano, syrup, and MNP-C groups decreased by 36.7, 40.8, and 37.9 percentage points, respectively (within-group, P < 0.05; between groups, P > 0.05). Costs per beneficiary ranged from $12.1 (MNP-C) to $94.8 (Nutrivida). CONCLUSIONS: The CCT program could distribute alternative supplements at lower cost per beneficiary without compromising potential for impact. Acceptance among beneficiaries should also be considered in choice of alternatives. This trial was registered at www.clinicaltrials.gov as NCT00531674.

Closing the Nutrition Impact Gap Using Program Impact Pathway Analyses to Inform the Need for Program Modifications in Mexico's Conditional Cash Transfer Program.

BACKGROUND: Mexico's Prospera-Oportunidades-Progresa Conditional Cash Transfer Program (CCT-POP) included the distribution of fortified food supplements (FFS) for pregnant and lactating women and young children. Rigorous evaluations showed significant impacts on nutrition outcomes but also substantial gaps in addressing nutrition problems. OBJECTIVES: To highlight the program design-related and implementation-related gaps and challenges that motivated further research and the eventual design and roll-out of a modified nutrition component for CCT-POP. METHODS: We used a program impact pathway approach to highlight the extent and quality of implementation of CCT-POP, and its impact on nutrition outcomes. We drew on previously published and new primary data, organized into 3 sources: impact evaluations, studies to inform reformulation of the FFS, and a longitudinal follow-up study using qualitative and quantitative methods to document FFS use and the dietary intake of women and children. RESULTS: Despite positive impacts, a high prevalence of malnutrition persisted in the population. Coverage and use of health services improved, but quality of care was lacking. Consumption of FFS among lactating women was irregular. Micronutrient intake improved among children who consumed FFS, but the pattern of use limited frequency and quantity consumed. Substantial diversity in the prevalence of undernutrition was documented, as was an increased risk of overweight and obesity among women. CONCLUSIONS: Three key design and implementation challenges were identified. FFS, although well accepted for children, had limited potential to substantially modify the quality of children's diets because of the pattern of use in the home. The communications strategy was ineffective and ill-suited to its objective of motivating FFS use. Finally, the program with its common design across all regions of Mexico was not well adapted to the special needs of some subgroups, particularly indigenous populations. The studies reviewed in this paper motivated additional research and the eventual redesign of the nutrition component.

[Stunting in children population in localities under 100 000 inhabitants in Mexico.] / Desnutrición crónica en población infantil de localidades con menos de 100 000 habitantes en México.

OBJECTIVE: To describe the undernutrition prevalence, as well as some sociodemographic characteristics associated to stunting in children under five years old, living on locali- ties with less than 100 000 inhabitants in Mexico in 2012 and 2018. MATERIALS AND METHODS: Low weight, stunting and wasting prevalences were calculated in children under 5y according to WHO Growth Reference. A comparison of stunting by sociodemographic and diet diversity variables is presented. Multi-variated logistic models between chronic malnutrition and sociodemographic variables were calculated. RESULTS: In 2018, 4.4% of the individuals suffered low weight, 14.9% stunting and 1.5 % wasting. Stunting was greater in indigenous households (24.5%), households from the lower socioeconomic-index tertile (17.5%), and households with moderated/severe food insecurity (15.3%). Stunting was positively associated with indigenous condition; on the other hand a highly diverse diet resulted to be a protective factor against it. CONCLUSIONS: A high prevalence of chronical malnutrition was documented associated with high poverty conditions. It is important to enforce strategies aimed to contain it, mainlyin such populations with greater social deprivation.

OBJETIVO: Describir la prevalencia de desnutrición infantil y algunas características sociodemográficas asociadas con la desnutrición crónica en menores de cinco años, de localidades de menos de 100 000 habitantes en 2012 y 2018 en México. MATERIAL Y MÉTODOS: Se calcularon prevalencias de bajo peso, desnutrición crónica y emaciación. Se presenta la comparación de la desnutrición crónica por variables sociodemográficas y de diversidad dietética. Se probaron modelos logísticos multivariados entre desnutrición crónica y variables sociodemográficas. RESULTADOS: En 2018, 4.4% presentó bajo peso, 14.9% desnutrición crónica y 1.5% emaciación. La desnutrición crónica fue mayor en hogares indígenas (24.5%), hogares de mayores carencias socioeconómicas (17.5%) y hogares con inseguridad alimentaria moderada/severa (15.3%). La desnutrición crónica se asoció positivamente con habitar hogar indígena y la alta diversidad dietética resultó factor protector de desnutrición crónica. CONCLUSIONES: Se documenta una alta prevalencia de desnutrición crónica asociada con condiciones de alta marginalidad. Es importante fortalecer estrategias diseñadas para contener la desnutrición, sobre todo en las poblaciones de mayores carencias sociales.

Desnutrición crónica en población infantil de localidades con menos de 100 000 habitantes en México / Stunting in children population in localities under 100 000 inhabitants in Mexico

Resumen: Objetivo: Describir la prevalencia de desnutrición infantil y algunas características sociodemográficas asociadas con la desnutrición crónica en menores de cinco años, de localidades de menos de 100 000 habitantes en 2012 y 2018 en México. Material y métodos: Se calcularon prevalencias de bajo peso, desnutrición crónica y emaciación. Se presenta la comparación de la desnutrición crónica por variables sociodemográficas y de diversidad dietética. Se probaron modelos logísticos multivariados entre desnutrición crónica y variables sociodemográficas. Resultados: En 2018, 4.4% presentó bajo peso, 14.9% desnutrición crónica y 1.5% emaciación. La desnutrición crónica fue mayor en hogares indígenas (24.5%), hogares de mayores carencias socioeconómicas (17.5%) y hogares con inseguridad alimentaria moderada/severa (15.3%). La desnutrición crónica se asoció positivamente con habitar hogar indígena y la alta diversidad dietética resultó factor protector de desnutrición crónica. Conclusiones: Se documenta una alta prevalencia de desnutrición crónica asociada con condiciones de alta marginalidad. Es importante fortalecer estrategias diseñadas para contener la desnutrición, sobre todo en las poblaciones de mayores carencias sociales.

Abstract: Objective: To describe the undernutrition prevalence, as well as some sociodemographic characteristics associated to stunting in children under five years old, living on localities with less than 100 000 inhabitants in Mexico in 2012 and 2018. Material and methods: Low weight, stunting and wasting prevalences were calculated in children under 5y according to WHO Growth Reference. A comparison of stunting by sociodemographic and diet diversity variables is presented. Multi-variated logistic models between chronic malnutrition and sociodemographic variables were calculated. Results: In 2018, 4.4% of the individuals suffered low weight, 14.9% stunting and 1.5 % wasting. Stunting was greater in indigenous households (24.5%), households from the lower socioeconomic-index tertile (17.5%), and households with moderated/severe food insecurity (15.3%). Stunting was positively associated with indigenous condition; on the other hand a highly diverse diet resulted to be a protective factor against it. Conclusions: A high prevalence of chronical malnutrition was documented associated with high poverty conditions. It is important to enforce strategies aimed to contain it, mainly in such populations with greater social deprivation.

Height Trajectory During Early Childhood Is Inversely Associated with Fat Mass in Later Childhood in Mexican Boys.

BACKGROUND: Childhood obesity continues to be a global health problem. Previous research suggests that linear growth retardation or stunting during early childhood increases the risk of obesity, but others have reported that rapid linear growth poses a greater concern than early nutritional status. OBJECTIVE: The objective of this study was to determine if growth trajectories are associated with body composition at age 8-10 y. METHODS: Study participants consisted of 255 girls and 281 boys who participated in a follow-up of the Prenatal Omega-3 Fatty Acid Supplementation and Child Growth and Development (POSGRAD) Study. Sex-specific latent height class (LHC) trajectories were derived from 11 measures of height from birth to 5 y of age and used to calculate 3 distinct growth classes for boys (low, intermediate, and high) and 2 distinct classes for girls (low and high). Body composition at age 8-10 y was estimated using bioelectrical impedance analysis. Multivariable linear regression analysis was used to determine the relationship between growth trajectory classes and fat mass (FM) and fat-free mass (FFM) in late childhood, controlling for confounding factors. RESULTS: In girls, there were no significant associations between LHC and FM or FFM. In boys, relative to the intermediate LHC, the low LHC had higher FM (ß = 0.69 kg; 95% CI: 0.26-1.11 kg) and the high LHC had lower FM (ß = -0.40 kg; 95% CI: -0.76 to -0.05 kg). Boys in the low LHC had significantly less FFM (ß = -0.69 kg; 95% CI: -1.11 to -0.26 kg), and boys in the high LHC had more FFM (ß = 0.40 kg; 95% CI: 0.05-0.76 kg) compared with the intermediate LHC. CONCLUSION: Gain in height among boys, but not girls, in early childhood was associated with lower adiposity in late childhood compared with children with a slower rate of growth. Clinical trial registration number: NCT00646360.

Dietary intake and adequacy in Mexican preschool children: National Health and Nutrition Survey 2012.

OBJECTIVE: to estimate energy, nutrient intake and diet adequacy in preschool-aged children based on data from the Mexican National Health and Nutrition Survey 2012. MATERIAL AND METHODS: dietary data in children < 5 years (n = 1,212) collected through a Semi-quantitative Food Frequency Questionnaire (SFFQ) were analyzed. Energy and daily nutrient intakes and adequacies were calculated comparing by sociodemographic characteristics. RESULTS: median daily energy intake was 1,252 kcal (adequacy 104%). Adequacies above 100% were observed for calcium, zinc, vitamin C, folate, vitamin B12, vitamin A and median of saturated fat. Low percent adequacies were observed for fiber, iron, polyunsaturated fat and vitamin D. Intakes were lower in the southern region compared to other regions. Most intakes and adequacies were higher in urban compared to rural areas, but fiber had the opposite trend. Indigenous children had low intakes and percent adequacies. CONCLUSIONS: risks of dietary deficiencies and excess are present in Mexican preschool-aged children, with marked differences across sociodemographicstrata.

Dietary intake and adequacy in mexican preschool children: national health and nutrition survey 2012 / Ingesta dietética y adecuación en preescolares mexicanos: Encuesta Nacional de Nutrición y Salud 2012

Objective: to estimate energy, nutrient intake and diet adequacy in preschool-aged children based on data from the Mexican National Health and Nutrition Survey 2012.Material and methods: dietary data in children < 5 years (n = 1,212) collected through a Semi-quantitative Food Frequency Questionnaire (SFFQ) were analyzed. Energy and daily nutrient intakes and adequacies were calculated comparing by sociodemographic characteristics. Results: median daily energy intake was 1,252 kcal (adequacy 104%). Adequacies above 100% were observed for calcium, zinc, vitamin C, folate, vitamin B12, vitamin A and median of saturated fat. Low percent adequacies were observed for fiber, iron, polyunsaturated fat and vitamin D. Intakes were lower in the southern region compared to other regions. Most intakes and adequacies were higher in urban compared to rural areas, but fiber had the opposite trend. Indigenous children had low intakes and percent adequacies. Conclusions: risks of dietary deficiencies and excess are present in Mexican preschool-aged children, with marked differences across sociodemographicstrata

Objetivo: estimar la ingesta de energía, nutrimentos y adecuación de la dieta de preescolares mexicanos de la Encuesta Nacional de Salud y Nutrición 2012. Material y métodos: se recogieron los datos dietéticos de niños < 5 años (n = 1.212) a través de un cuestionario semicuantitativo de frecuencia de consumo de alimentos (CSFCA). El consumo y la adecuación de energía y nutrimentos fueron calculados según las características sociodemográficas. Resultados: la mediana de ingesta de energía fue de 1.252 kcal (adecuación 104%). Se hallaron adecuaciones mayores al 100% para calcio, zinc, vitamina C, folato, vitamina B12, vitamina A y mediana de grasa saturada. Se observaron adecuaciones bajas para fibra, hierro, grasa poliinsaturada y vitamina D, e ingesta menor para la región sur comparada con otras regiones. Las ingestas y adecuaciones fueron más altas en área urbana en comparación con el área rural, excepto para fibra. Los niños indígenas presentaron ingestas y adecuaciones bajas. Conclusiones: la dieta de niños preescolares mexicanos presenta riesgo de deficiencias y excesos, con marcadas diferencias entre estratos Sociodemográficos

Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight.

BACKGROUND: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsaturated fatty acids (PUFAs) into their long-chain active form. A high prevalence of SNPs that are associated with slow PUFA conversion has been described in Hispanic populations. OBJECTIVE: We assessed the heterogeneity of the effect of prenatal supplementation with docosahexaenoic acid (DHA) on birth weight across selected FADS SNPs in a sample of Mexican women and their offspring. DESIGN: We obtained information on the maternal genotype from stored blood samples of 654 women who received supplementation with 400 mg DHA/d or a placebo from weeks 18 to 22 of gestation through delivery as part of a randomized controlled trial conducted in Cuernavaca, Mexico. We selected 4 tag SNPs (rs174455, rs174556, rs174602, and rs498793) in the FADS region for analysis. We used an ANOVA to test for the heterogeneity of the effect on birth weight across each of the 4 SNPs. RESULTS: The mean ± SD birth weight was 3210 ± 470 g, and the weight-for-age z score (WAZ) was -0.24 ± 1.00. There were no intention-to-treat differences in birth weights. We showed significant heterogeneity by SNP rs174602 (P= 0.02); offspring of carriers of alleles TT and TC in the intervention group were heavier than those in the placebo group (WAZ: -0.13 ± 0.14 and -0.20 ± 0.08 compared with -0.55 ± 0.15 and -0.39 ± 0.09, respectively); there were no significant differences in offspring of rs174602 CC homozygotes (WAZ: -0.26 ± 0.09 in the intervention group compared with -0.04 ± 0.09 in the placebo group). We showed no significant heterogeneity across the other 3 FADS SNPs. CONCLUSION: Differential responses to prenatal DHA supplementation on the basis of the genetic makeup of target populations could explain the mixed evidence of the impact of DHA supplementation on birth weight. This trial was registered at clinicaltrials.gov as NCT00646360.

Prenatal Supplementation with Docosahexaenoic Acid Has No Effect on Growth through 60 Months of Age.

BACKGROUND: Prenatal supplementation with docosahexaenoic acid (DHA) has been shown to increase birth size, but it is unclear whether these differences translate into improved postnatal growth. OBJECTIVE: We assessed the effect of prenatal supplementation with DHA on offspring weight, length, and body mass index (BMI) through 60 mo of age. METHODS: We examined growth patterns (height, weight, and BMI) in a cohort of 802 Mexican children whose mothers participated in a randomized, controlled trial of daily supplementation with 400 mg/d of DHA or a placebo from week 18-22 of gestation through delivery, with the use of a longitudinal multilevel model of growth. RESULTS: Overall, means ± SDs of height-, weight-, and BMI-for-age z scores relative to WHO growth standards at 60 mo were -0.49 ± 0.91, -1.15 ± 1.07 and 0.13 ± 1.11, respectively. There were no significant differences by treatment group (all P > 0.05) for height, weight, or BMI at any age through 60 mo. Similarly, DHA did not affect the average growth or the trajectories for these measures through 60 mo. CONCLUSION: Prenatal DHA supplementation did not affect height, weight, or BMI through 60 mo of age. This trial was registered at clinicaltrials.gov as NCT00646360.

[Stunting in Mexico in the last quarter century: analysis of four national surveys]. / Desnutrición crónica en México en el último cuarto de siglo: análisis de cuatro encuestas nacionales.

OBJECTIVE: To describe the magnitude, distribution, and trends of undernutrition and overweight from 1988 to 2006, and provide recommendations for their erradication. MATERIALS AND METHODS: Antrhopometric indicators of nutritional status in children <5 y from four surveys were analyzed. RESULTS: Despite its significant reduction in the study period, stunting remains as a public health problem, with the highest prevalences in indigenous population, the rural south and the lowest living conditions quintile. CONCLUSIONS: Several policies and programs have demonstrated effectiveness, but implementation challenges persist among the poorest population, particularly in indigenous households. Measures for improving the effectiveness of the nutrition policies and programs, particularly among the indigenous and poorest population, are provided, which include adjusting current programs according to the results of evaluations, and the implementation of policies that address the social determinants of undernutrition.

Desnutrición crónica en México en el último cuarto de siglo: análisis de cuatro encuestas nacionales / Stunting in Mexico in the last quarter century: analysis of four national surveys

Objetivo. Describir la magnitud, distribución y tendencias de la desnutrición y el sobrepeso en menores de 5 años de 1988 a 2012 y hacer recomendaciones para su erradicación. Material y métodos. Se analizaron indicadores antropométricos en menores de 5 años, de cuatro encuestas nacionales. Resultados. A pesar de haber tenido un notable descenso en el periodo estudiado, la desnutrición crónica persiste como problema de salud pública, con mayores prevalencias en la población indígena, las zonas rurales del sur y el quintil de menores condiciones de bienestar. Conclusiones. Diversas políticas y programas han mostrado efectividad aunque persisten retos de implementación entre la población más pobre, particularmente la indígena. Se recomiendan, por una parte, medidas para aumentar la efectividad de las políticas y programas actuales, sobre todo entre la población indígena y la más pobre, mediante el ajuste de los programas actuales, de acuerdo con los resultados de las evaluaciones y, por la otra, políticas de desarrollo social que atiendan los determinantes sociales de la desnutrición.

Objective. To describe the magnitude, distribution, and trends of undernutrition and overweight from 1988 to 2006, and provide recommendations for their erradication. Materials and methods. Antrhopometric indicators of nutritional status in children <5 y from four surveys were analyzed. Results. Despite its significant reduction in the study period, stunting remains as a public health problem, with the highest prevalences in indigenous population, the rural south and the lowest living conditions quintile. Conclusions. Several policies and programs have demonstrated effectiveness, but implementation challenges persist among the poorest population, particularly in indigenous households. Measures for improving the effectiveness of the nutrition policies and programs, particularly among the indigenous and poorest population, are provided, which include adjusting current programs according to the results of evaluations, and the implementation of policies that address the social determinants of undernutrition.

Nutritional status of indigenous children younger than five years of age in Mexico: results of a national probabilistic survey.

OBJECTIVE: To compare the prevalence of undernutrition and anemia in indigenous and non-indigenous children < 5 years of age at the national level, by region and by urban and rural areas, and to evaluate the degree to which the socioeconomic condition of the family predicts the differences. MATERIAL AND METHODS: A national probabilistic survey was conducted in Mexico in 1999. Indigenous families were identified as those in which at least one woman 12-49 years of age in the household spoke a native language. The prevalence of undernutrition (stunting, wasting and underweight) and anemia was compared between indigenous and non-indigenous children. Probability ratios (PR) were used to compare prevalences in indigenous and non-indigenous children adjusting for socioeconomic status (SES) of the family and for other covariates. RESULTS: The prevalences of stunting and underweight were greater in indigenous than in non-indigenous children. At the national level and in urban areas the prevalences were three times greater and in rural areas approximately 2 times greater (p < 0.05). No differences were found in the prevalence of wasting (p > 0.05). The prevalence of anemia in indigenous children was one third greater than in non-indigenous children at the national level (p < 0.05) and was between 30 and 60% greater in urban areas and in the regions studied (p < 0.05) but was not statistically significant (p > 0.05) in rural areas. These differences were reduced to about half when adjusting for SES but remained significantly higher in indigenous children (p < 0.05). CONCLUSIONS: Indigenous children have higher probabilities of stunting and underweight than non-indigenous children. The differences are larger in urban areas and in higher socioeconomic geographic regions and are explained mostly by socioeconomic factors. The overall difference in the probability of anemia is small, is higher only in urban relative to rural areas, and is explained to a lesser degree by socioeconomic factors. Policy and programs should be designed and implemented to reduce the dramatic differences in nutritional status between indigenous and non-indigenous children in Mexico. The English version of this paper is available too at: http://www.insp.mx/salud/index.html.

Factors associated with overweight and obesity in Mexican school-age children: results from the National Nutrition Survey 1999.

OBJECTIVE: The objective of the study was to measure the prevalence of overweight and obesity in Mexican school-age children (5-11 years) in the National Nutrition Survey 1999 (NNS-1999). MATERIAL AND METHODS: Overweight and obesity (defined as an excess of adipose tissue in the body) were evaluated through the Body Mass Index (BMI) in 10,901 children, using the standard proposed by the International Obesity Task Force. Sociodemographic variables were obtained using a questionnaire administered to the children's mothers. RESULTS: The national prevalence of overweight and obesity was reported to be 19.5%. The highest prevalence figures were found in Mexico City (26.6%) and the North region (25.6%). When adjusting by region, rural or urban area, sex, maternal schooling, socioeconomic status, indigenous ethnicity and age, the highest prevalences of overweight and obesity were found among girls. The risks of overweight and obesity were positively associated with maternal schooling, children's age and socioeconomic status. CONCLUSIONS: Overweight and obesity are prevalent health problems in Mexican school-age children, particularly among girls, and positively associated with socioeconomic status, age, and maternal schooling. This is a major public health problem requiring preventive interventions to avoid future health consequences. The English version of this paper is available too at: http://www.insp.mx/salud/index.html.